Emirates Airlines boss Sir Tim Clark made the controversial comments in an interview with German magazine Der Spiegel.
“MH370 was, in my opinion, under control, probably until the very end,” he said.
His theory goes against current thinking that the aircraft was on autopilot until it ran out of fuel and crashed into the southern Indian Ocean.
He added: “Our experience tells us that in water incidents, where the aircraft has gone down, there is always something.
We have not seen a single thing that suggests categorically that this aircraft is where they say it is, apart from this so-called electronic satellite ‘handshake’, which I question as well.”
The plane that disappeared was a Boeing 777 and Emirates operates 127 such aircraft, more than any other airline.
Sir Tim said he was suspicious of the fact that no-one seems to know where the plane ended up.
“There hasn’t been one over-water incident in the history of civil aviation – apart from Amelia Earhart in 1939 – that has not been at least 5 or 10% trackable.
“But MH370 has simply disappeared. For me, that raises a degree of suspicion. I’m totally dissatisfied with what has been coming out of all of this,” he told the magazine.
Sir Tim called for more transparency in the investigation.