The pilot of the single-engine aircraft attempted to touch down on route 116 in Hanna City.
Witnesses say the plane made a sputtering sound as it clipped several buildings in attempting to land on the street.
A woman inside was killed on impact, while a man was pulled out by first responders and died a short time later.
It’s not clear which person was piloting the single-engine Mooney aircraft.
The Peoria County coroner has scheduled an autopsy for the victims on Monday.
The FAA and the National Transportation Safety Board is expected to investigate the crash.