To achieve a 4000-nm range, Airbus has envisioned a configuration carrying 206 passengers (16J and 190Y). They have also stated that, due to the extra fuel tank and limitations of the design, it is unlikely for this aircraft to be able to carry much cargo. This may, immediately, appear as a source of consternation if your airline relies on flying long sorties on narrow-bodies full of fresh fish. Otherwise, is it really a big deal? I would say no.
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